Erythrodermic Psoriasis Treated with Apremilast
نویسندگان
چکیده
Erythroderma is a rare potentially deadly exfoliative dermatitis characterized by diffuse cutaneous erythema which may be associated with multi-organ dysfunction. Therefore, it is imperative to recognize and treat it promptly. Erythrodermic psoriasis is the most common form of erythroderma. Management of this condition is largely based on aggressive supportive care and the use of anti-inflammatory immunosuppressive and biologic agents. We describe a case of psoriatic erythroderma which was triggered by withdrawal from systemic steroids and successfully treated with apremilast and cyclosporine. Apremilast induced atrial fibrillation limited its continued use after the initial response period.
منابع مشابه
Pediatric psoriasis treated with apremilast
BSA: body surface area INTRODUCTION Psoriasis is a cutaneous, chronic inflammatory disorder that affects approximately 3.1% of US adults younger than 60 years and up to 2.1% of children worldwide. Chronic plaque psoriasis is generally the most common type of childhood psoriasis (accounting for 74% of cases in one study), followed by guttate psoriasis (9.7%-28.9%), which is often triggered by st...
متن کاملErythrodermic psoriasis with bullous pemphigoid: combination treatment with methotrexate and compound glycyrrhizin
UNLABELLED We report a case of erythrodermic psoriasis with bullous pemphigoid (BP) in a 68-year-old male. The patient had a history of psoriasis for 35 years and tense, blisterlike lesions for 4 months. He presented with diffuse flushing, infiltrative swelling, and tense blisterlike lesions on his head, trunk, and limbs. This patient was successfully treated by a combination of methotrexate an...
متن کاملUstekinumab Treatment of Erythrodermic Psoriasis Occurring after Physical Stress: A Report of Two Cases
Erythrodermic psoriasis (EP) is a severe form of psoriasis precipitated by numerous factors, including physical stress, infections, and drugs. The disease represents a therapeutic challenge, and little is known about its response to ustekinumab. Though the efficacy of ustekinumab has been extensively studied in chronic plaque psoriasis, no trials have been carried out in EP. We report the case ...
متن کاملNew developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast
Psoriasis is a chronic inflammatory skin disease, most commonly resulting in the occurrence of red and silver scaly plaques. About 30% of psoriasis sufferers develop psoriatic arthritis (PsA), a disorder that presents with additional joint inflammation and other clinical features. At present, the most effective treatment for moderate and severe psoriasis and PsA are biologics such as antitumor ...
متن کاملGeneralized pustular psoriasis treated with apremilast in a patient with multiple medical comorbidities
G eneralized pustular psoriasis (GPP), von Zumbusch type, is an uncommon variant of psoriasis characterized by acute-onset severe inflammation and widespread sterile pustules within psoriatic plaques. GPP is a medical emergency that often requires hospitalization because of possible life-threatening complications, including heart failure, renal failure, and sepsis. Existing treatment options fo...
متن کامل